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Toxicity to aquatic algae and cyanobacteria

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Description of key information

Acutely harmful to aquatic algae.

Key value for chemical safety assessment

Additional information

No experimental data are available, considering the toxicity of phenetyhlamine (CAS 64 -04 -0) to aquatic algae and cyanobacteria. Therefore, the assessment is based on a weight-of-evidence approach by read-across data for the structurally analogous substances DL-alpha-methylbenzylamine (CAS 618 -36 -0), L-alpha-methylbenzylamine (CAS 2627 -86 -3), 1 -phenylmethanamine (100 -46 -9) and 1 -phenylethanamine (CAS 3886 -69 -9).

Read-across data for DL-alpha-methylbenzylamine (CAS 618 -36 -0):

In a GLP-guideline study conducted according to OECD 201 with Pseudokirchneriella subcapitata as test organism, a 72-h ErC50 was determined to be 31.66 mg/L and the ErC10 to be 9.17 (based on nominal test concentrations, analytically verified, not neutralised) (BASF SE, 2012, study code: W/26/12; project no. 60E0728/11X317).

Read-across data for L-alpha-methylbenzylamine (CAS 2627 -86 -3):

In a GLP-guideline study according to OECD 201 with Pseudokirchneriella subcapitata as test organism, a 72-h ErC50 of 37.9 mg/L and a 72 -h ErC10 of 12.1 mg/L were determined (based on nominal test concentrations, analytically verified, not neutralised) (BASF SE, 2012, study code: W/28/12; project no. 60E0729/11X292).

 

Read-across data for phenylmethanamine (CAS 100 -46 -9):

In a GLP-guideline study according to EU Method C.3 and equivalent or similar to OECD 201 with Desmodesmus subcapitatus as test organism, a 72 -h ErC50 of 50 mg/L and a 72 -h ErC10 of 17.0 mg/L were determined (based on nominal test concentrations, analytically verified, not neutralised) (Currenta, 2010, report no. 2010/0066/02).

In a second study with Scenedesmus quadricauda as test organism, a 96 -h EC3 of 6 mg/L was determined (based on nominal concentrations, not neutralised) (Bringmann and Kuehn, 1959, Vergleichende wasser-toxikologische Untersuchung an Bakterien, Algen und Kleinkrebsen). However, this study is disregarded due to major methodological deficiencies.

Read-across data for phenylethanamine (3886 -69 -9):

In a GLP-guideline study according to OECD 201 with Pseudokirchneriella subcapitata as a test organism, a 72 -h ErC50 of 16.4 mg/L and a 72 -h ErC10 of 4.7 mg/L were determined (based on nominal test concentrations, analytically verified, not neutralised) (BASF SE, 2012, study code: W/31/12; project no. 60E0730/11X319).


In summary, phenethylamine is considered acutely and chronically harmful to aquatic algae and cyanobacteria.