Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Acutely harmful to fish.

Key value for chemical safety assessment

Additional information

There is one reliable study available regarding the toxic effect of phenethylamine (CAS 64 -04 -0; BASF AG, 1985; report no: 84/416). The study was performed according to DIN 38412, part 15 with Leuciscus idus as test species.The nominal concentrations were 10, 14.7, 21.5, 31.6, 46.4, 68.1 mg/L (not pH-adjusted). In addition, the highest test solution (68.1 mg/L) was also tested after pH-adjustment. The test concentrations were not analytically verified, but are assumed to be stable due to the low n-octanol/water partition coefficient (log Kow = -1.35), the high water solubility (WS = 1.0E+06 mg/L at 25 °C), the vapour pressure (VP =54.5 Pa at 25°C) and the low Henry´s law constant (HLC, uncharged: 8.23E-02 Pa*m3/mol) of the chemical.

Based on nominal test concentrations, the 96-h LC50 was determined to be 38.3 mg/L for non-neutralised test solutions. The pH-adjustment reduced effects on fish significantly. No mortality and not symptoms were observed at the highest test concentrations (pH-adjusted: 96-h NOEC 68.1 mg/L).

A non-guideline study regarding acute oral toxicity to Cyprinus carpio was not considered for this evaluation, due to methodological deficiencies (Loeb & Kelly, 1963).

In conclusion, phenethalamine is considered acutely harmful to fish.