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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
Not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Effect of Dietary Zinc on the Absorption of Orally Administered Zn65
Author:
Furchner JE & Richmond CR
Year:
1962
Bibliographic source:
Health Phys. 8:35-40

Materials and methods

Study type:
not specified
Endpoint addressed:
basic toxicokinetics
Principles of method if other than guideline:
Effect of dietary zinc as Zinc acetate was evaluated on the absorption of orally administered Zn65.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Zinc chloride
EC Number:
231-592-0
EC Name:
Zinc chloride
Cas Number:
7646-85-7
Molecular formula:
Cl2Zn
IUPAC Name:
zinc dichloride
Details on test material:
- Name of test material (as cited in study report): Zinc chloride
- Specific activity (if radiolabelling): 1.2 µC

Method

Type of population:
general
Subjects:
- Number of subjects exposed: One
Ethical approval:
not specified
Route of exposure:
oral
Reason of exposure:
intentional
Exposure assessment:
measured
Details on exposure:
Same subject exposed to Zn65 twice with an interval of 700 d. Diet containing 10 mg of Zinc (as Zinc acetate) was administered for 30 d before the second ingestion of Zn65.
Examinations:
Whole-body activity was determined at 30 min and at 1, 2, 4, 7 and 11 d after injection in the Los Alamos Small Animal Counter (LASAC-III)
Medical treatment:
Not applicable

Results and discussion

Clinical signs:
No data
Results of examinations:
- At 10 d post-ingestion, excretion increased by more than a factor of 3
- Radioassay of fecal samples showed that, after the first ingestion, 11 per cent of the Zn65 was excreted during the first 4 d post ingestion and that, after the second ingestion, 44 per cent was excreted during the first 3 d post ingestion.

For details, see figure 1 & 5 in the reference.
Effectivity of medical treatment:
Not applicable
Outcome of incidence:
Not applicable

Any other information on results incl. tables

Result of study on rats:

- Retention of Zinc from Zn62Cl in rats fed with normal dietary zinc (~58 ppm) was determined to be 20.22 ± 3.30, 14.86 ± 2.44, 12.73 ± 2.17, 10.74 ± 1.90 and 9.22 ± 1.70 at 1, 2, 4, 7 and 11 d, respectively.

Applicant's summary and conclusion

Conclusions:
Under the test conditions, data from one human suggest that dietary zinc is a factor regulating the amount of Zinc retained in humans.
Executive summary:

A study was conducted to evaluate the effect of dietary zinc as Zinc acetate on the absorption of orally administered Zn65.

 

Same human subject was exposed to Zn65 twice with an interval of 700 d. Diet containing 10 mg of Zinc (as Zinc acetate) was administered for 30 d before the second ingestion of Zn65.

 

Radioassay of fecal samples showed that, after the first ingestion, 11 per cent of the Zn65 was excreted during the first 4 d post ingestion and that, after the second ingestion, 44 per cent was excreted during the first 3 d post ingestion. Analysis of the data from rats and human subject attributed the difference to inhibited absorption.

 

Under the test conditions, data from one human suggest that dietary zinc is a factor regulating the amount of Zinc retained in humans.

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