Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: In this record a summary of a report on accidental eye exposure to liquid vinyl chloride is provided. The study has been published in peer-reviewed literature and is considered adequate for assessment.

Data source

Reference
Reference Type:
publication
Title:
Chemical Burns of the Human Cornea
Author:
McLaughlin, R.S
Year:
1946
Bibliographic source:
Am. J. Ophthalmol., Vol. 29, 1355 - 1362

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
eye irritation
Principles of method if other than guideline:
Case report
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroethylene
EC Number:
200-831-0
EC Name:
Chloroethylene
Cas Number:
75-01-4
Molecular formula:
C2H3Cl
IUPAC Name:
chloroethene

Method

Type of population:
general

Results and discussion

Results of examinations:
Chemical burns of the cornea after spray accident with liquid vinyl chloride (presumably due to hypothermal effect). Treatment with denuding technique. Prompt healing with 48 h. 

Applicant's summary and conclusion