Registration Dossier
Registration Dossier
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EC number: - | CAS number: 2156592-70-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: Experimental study with a similar substance
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Dodecylbenzene
- EC Number:
- 204-591-8
- EC Name:
- Dodecylbenzene
- Cas Number:
- 123-01-3
- IUPAC Name:
- dodecylbenzene
- Reference substance name:
- Benzene, dodecyl
- IUPAC Name:
- Benzene, dodecyl
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 07651 B8 008
- Molecular formula (if other than submission substance): C18H30
- Molecular weight (if other than submission substance): 246 g
- Physical state: colorless liquid
- Lot/batch No.: O.E. 241
- Stability under test conditions: stable
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- ICR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Les Oncins
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 5-7 weeks
- Housing: polycarbonate cages 305*180*184 mm
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+-3ºC
- Humidity (%): 30-70% RH
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): 7:30-19:30
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2004 mg/kg (2.33 ml/kg)
- No. of animals per sex per dose:
- preliminary study: 4 males/ 4 females
full study: 10 males / 10 females
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 004 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no
- Clinical signs:
- other: no
- Gross pathology:
- not observed effects
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study a LD0 >=2004 mg/kg bw was observed (no mortalities)
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