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EC number: - | CAS number: 2156592-70-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: Experimental study with similar substance
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Remarks:
- The study director, M. Lheritier, from Hazleton France, confirmed that the test was performed according to GLP rules.
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Dodecylbenzene
- EC Number:
- 204-591-8
- EC Name:
- Dodecylbenzene
- Cas Number:
- 123-01-3
- IUPAC Name:
- dodecylbenzene
- Details on test material:
- Molecular formula ; C18H30
Molecular weight : 240 g
Batch number : O E 241
Constituent 1
Test animals
- Species:
- rat
- Strain:
- ICR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adults, 5 to 7 weeks old, housing in sex and in group of 2 (for the preliminary study) in group of 5 (for the main study) in polycarbonat cages, temperature ranging from 19 to 25°C, humidity 30 to 70 % R.H., lighting 12 hour light-dark cycle, fed ad libitum with rat-mouse pelleted complete maintenance diet, free access to softened and filtered drinking water
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Use of a curved oesophage probe in stainless steel
- Doses:
- Preliminary study : 3 groups of 2 males and 2 females each were treated with dose of 507, 1006 and 2004 mg/kg.
Main study : as there was no death at dose level of 2004 mg/kg during the preliminary treatment, a unique of 2004 mg/kg was administrated to 5 males and 5 females. - No. of animals per sex per dose:
- Preliminary study : 3 groups of 2 males and 2 females per dose
Main study : 5 males and 5 females per dose - Control animals:
- yes
- Details on study design:
- Main study : a single dose of the undiluted test material was administered to ten animals at a dose level of 2 004 mg/kg. A control group was included.
The animals were observed for signs of behavioral changes at the end of gavage and during the 14 following days. The weight change of the
tested animals was identical to that of the control group. All animals were euthanized at the conclusion of the observation period. Autopsies were performed on all animals (J15).
Results and discussion
- Preliminary study:
- The preliminary study at dose levels 507, 1006 and 2004 mg/kg did not show any effect on the tested animals.
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- > 2 004 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- > 2 004 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the tested animals died.
- Clinical signs:
- other: No pathological clicical sign was observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to this experiment the LD0 for linear dodecylbenzene is > 2004 mg/kg. As branching does not impact toxicity and to avoid unnecessary animal testing we considered that same result can be applied to our substance, C12 branched alkylbenzene.
- Executive summary:
A single dose of the undiluted test material was administered to ten animals at a dose level of 2004 mg/kg. A control group was included. The animals were observed for signs of behavioral changes at the end of gavage and during the 14 following days. The weight change of the tested animals was identical to that of the control group. All animals were euthanized at the conclusion of the observation period. Autopsies were performed on all animals (J15). No treatment related gross postmortem findings were evident at necropsy.
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