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EC number: 215-199-1
CAS number: 1312-76-1
The first and the second reading of the
historical positive control group gave 6/10 animals with positive
reactions whereas the corresponding negative control group (5 animals)
gave no reactions at both time points.
RESULTS OF PILOT STUDY: minimal irritating concentration: 6%; maximal non-irritating concentration: 4%
RESULTS OF TEST
- Sensitization reaction: sensitization with 2-6% did not significantly alter cell proliferation in the auricular lymph nodes,
even though an increase of 30% and 40% at the 4% and 6% treatment levels was measured, respectively. A greater than
30-fold increase was measured in the positive control.
Potassium silicate as well as the
read-across substance, sodium metasilicate, were not sensitizing in two
different skin sensitisation tests (Buehler test and local lymph node
assay). In a human case report, contact urticaria induced by sodium
silicate was observed in one individual.
Migrated from Short description of key information:
Potassium silicate is not sensitising.
Not required. No data available.
The available data is conclusive but not
sufficient for classification.
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