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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, but no information on purity of test substance.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1990
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2004
Report date:
2004

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes
Remarks:
Pharmatox Beratung und Forschung GmbH

Test material

Constituent 1
Chemical structure
Reference substance name:
Silicic acid, potassium salt
EC Number:
215-199-1
EC Name:
Silicic acid, potassium salt
Cas Number:
1312-76-1
Molecular formula:
K2O x (SiO2)n with Molar Ratio (MR) (SiO2/K2O): 0.5 – 5 (with exception of MR = 1)
IUPAC Name:
potassium hydroxysilanoylolate
Details on test material:
SOURCE: Woellner Werke GmbH
PURITY: Not reported
IMPURITY/ADDITIVE/ETC.: Not reported
ANY OTHER INFORMATION: 29 wt% Potassium Silicate. Molar ratio 3.9

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 3.0 - 3.2 kg 

Test system

Vehicle:
water
Controls:
not required
Amount / concentration applied:
Concentration: 29 T49-004:wt%
Amount applied: 0.1 ml
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
6
Details on study design:
Comment: not rinsed
- Postexposure period: scoring done at 1, 2, 4, 8 hours and 1-7 days daily 
- Ophtalmoscopic examination: cornea, iris, conjunctiva
- Scoring system: according to OECD Guideline 405

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
1.5
Reversibility:
fully reversible within: 2 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0.7
Reversibility:
fully reversible within: 2 days

Any other information on results incl. tables

No further details on "results" available.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information