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Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Ulcerative contact dermatitis caused by sodium silicate. Coexistence of primary irritant contact dermatitis and contact urticaria.
Author:
Tanaka T et al.
Year:
1982
Bibliographic source:
Arch. Dermatol. 118, 518-520
Reference Type:
secondary source
Title:
Soluble Silicates. CAS No. 1344-09-8, 6834-92-0, 10213-79-3, 13517-24-3 and 1312-76-1.
Author:
OECD SIDS
Year:
2004

Materials and methods

Study type:
human medical data
Endpoint addressed:
skin sensitisation
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Case study observations
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Silicic acid, sodium salt
EC Number:
215-687-4
EC Name:
Silicic acid, sodium salt
Cas Number:
1344-09-8
Molecular formula:
Na2O x (SiO2)n with Molar Ratio (MR) (SiO2/Na2O): 1.5 – 4
IUPAC Name:
Silicic acid, sodium salt
Details on test material:
20 % sodium silicate solution of unknown molar ratio

Method

Type of population:
occupational
Ethical approval:
not applicable

Results and discussion

Results:
A fifty-seven year old dyer was regularly exposed at work to 20 % sodiumsilicate solution of unknown molar ratio. The man had recurrent ulcerative lesions on his left hand over a period of two years. The ulcers were associated with chronic eczematous changes resulting from primary irritant contact dermatitis to sodium silicate, as indicated by a positive patch test. The man also had another type of cutaneous reaction to sodium silicate, contact urticaria. An immediate wheal and flare reaction was seen fifteen minutes after the application of sodium silicate to a scratch test site. Such a response was not seen in healthy control subjects.

Applicant's summary and conclusion