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Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

basic toxicokinetics in vivo
Adequacy of study:
other information
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature, but generally accepted source. Taken from OECD SIDS on Sodium bicarbonate (2002).

Data source

Reference Type:
Proposed rules. Carbonates and bicarbonates. Proposed affirmation of GRAS status as direct and indirect human food ingredients
Food and Drug Administration,
Bibliographic source:
Federal Register, vol. 43, no. 114, p52440-52443

Materials and methods

Objective of study:
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium hydrogencarbonate
EC Number:
EC Name:
Sodium hydrogencarbonate
Cas Number:
Molecular formula:
sodium hydrogen carbonate

Test animals


Administration / exposure

Route of administration:
not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parametersopen allclose all
Toxicokinetic parameters:
half-life 2nd:
Toxicokinetic parameters:
half-life 1st:
Toxicokinetic parameters:
half-life 3rd:

Any other information on results incl. tables

The intraperitoneal injection of an unknown concentration of
sodium [14C] bicarbonate into CFW mice was followed by
assays (after 24 and 48 hrs and 1, 2, 4 and 12 weeks) of
blood, spleen, liver, kidneys, lungs, brain, jejenum,
muscle, skin, hair and long bones. More than 90% of the
total radioactivity injected was lost via the respiratory
route in one hour. At 24 hrs, most of the radioactivity in
the blood was in noncarbonate form. Specific activity in
long bones parallelled that in the blood for up to 12 weeks.
The radioactivity of the compound injected into a pregnant
mouse was fixed in the foetal tisssues more rapidly than in
the maternal tissues.
Variable and transient responses in erythrocyte counts and
hemoglobin levels in mice to orally administered sodium
bicarbonate was reported.

Applicant's summary and conclusion