Registration Dossier

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

short-term toxicity to fish
Type of information:
calculation (if not (Q)SAR)
Migrated phrase: estimated by calculation
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Automatic calculation with MeCLas Tool
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study
Principles of method if other than guideline:
Aquatic toxicity of the UVCB substance was determined by classifying based on Mixture rules from EU CLP ( tier 1= summation of classified components or Tier 2 = additivity of soluble components to derive Hazard class) and back calculation to the corresponding L(E)C50 range
96 h
Dose descriptor:
Effect conc.:
<= 1 mg/L
Nominal / measured:
Conc. based on:
test mat.
Basis for effect:
other: most sensitive species
Sublethal observations / clinical signs:

According to MeClas, the substance is classified as acute 1 to environment.

Validity criteria fulfilled:
Good quality estimate of the L/EC50 of the UVCB substance.
The substance is classified as acute cat 1 to environment resulting in a L(E)C50 < 1 mg/L.
Executive summary:

The study provided a conservative estimate of the effect concentration, derived on basis of the classification outcome (mixture toxicity rules) from a reasonable worst-case sample of the substance using mineralogical information from the representative sample. 


Validity of the model used:

1. Defined endpoint: the endpoint is a REACH compliant defined endpoint

2. Unambiguous algorithm: EU CLP guidance based summation formula to determine classification, followed by back-calculation to related hazard criteria

3. Applicability domain: applicable to classify complex metal containing materials. 

4. Mechanistic interpretation - metal species: the tool translates the elemental composition into a mineralogical composition relevant for classification.


Description of key information

No PNEC derived for the UVCB itself.

Short-term toxicity to fish is driven by the characteristics of the individual UVCB constituents. Relevant information on the individual UVCB constituents is reported in IUCLID Section 6 Summary. Individual UVCB constituents-specific information is used for classification and risk assessment.

Key value for chemical safety assessment

Additional information