Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 263-467-1 | CAS number: 62229-08-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Human lymphocytes were exposed to lead acetate alone (100 nM to 1 mM) or in combination with cadmium acetate or zinc acetate for three hours and chromosome abberations and gaps were examined.
- GLP compliance:
- not specified
- Type of assay:
- other: in vitro mammalian chromosome aberration test (migrated information)
Test material
- Reference substance name:
- Acetic acid, lead salt, basic
- EC Number:
- 257-175-3
- EC Name:
- Acetic acid, lead salt, basic
- Cas Number:
- 51404-69-4
Constituent 1
Results and discussion
Test results
- Species / strain:
- mammalian cell line, other: Human lymphocytes
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- not examined
- Remarks on result:
- other: Test system: all strains/cell types tested
Any other information on results incl. tables
Lead acetate exposure alone or in combination with cadmium and/or zinc did not increase the frequency of chromosome abberations or gaps at any concentration tested.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
- Executive summary:
Human lymphocytes were exposed to lead acetate alone (100 nM to 1 mM) or in combination with cadmium acetate or zinc acetate for three hours and chromosome abberations and gaps were examined. Lead acetate exposure alone or in combination with cadmium and/or zinc did not increase the frequency of chromosome abberations or gaps at any concentration tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
