Registration Dossier

Toxicological information

Endpoint summary

Currently viewing:

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Neodecanoic acid has been examined for skin sensitization potential in the guinea pig maximization procedure of Magnusson and Kligman.

 

Groups of ten male and ten female guinea pigs were used for the test and a further five males and five females as controls. 

 

Induction was accomplished in two stages. 

 

1) Intradermal injection

Two rows of three injections were made, one on each side of the midline in the shorn skin of the shoulder region. 

 

2) Topical application

One week after the intradermal injections, the same area was clipped free from hair. A 4x4 cm patch of filter paper was soaked in a solution of the test material and placed over the injection sites and covered with an occlusive dressing. The dressing was left in place for 48 hours. 

 

The challenge procedure was carried out two weeks after topical induction. Challenge was accomplished by topical application of the test material to the flank of animals via an occluded patch. The challenge lasted 24 hours. 

 

Immediately after the challenge, and then again at 24 and 48 hours later, each animals was examined for signs of skin sensitization.

 

At no point was there any evidence of skin sensitization produced by neodecanoic acid.   


Migrated from Short description of key information:
Not sensitizing.

Respiratory sensitisation

Endpoint conclusion
Additional information:

Neodecanoic acid is not expected to induce respiratory sensitization.

Justification for classification or non-classification

No classification for skin/respiratory sensitization is indicated according to the general classification and labelling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labelling, and packaging (CLP) regulation (EC) No 1272/2008.