Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-107-7
CAS number: 40039-93-8
Introduction: The study was performed to assess the acute dermal
toxicity of the test item in the Wistar strain rat. The method was
designed to be compatible with the following: OECD 402, B3 EC, EPA OPPTS
Method: A group of ten animals (five males and 5 females) was
given a single, 24 hour, semi-occluded dermal application of the test
item to intact skin at a dose levelof 2000mg/kg bodyweight. Clinical
signs and bidyweight development were monitored during the study. All
animals were subjected to gross necropsy.
Mortality: there were no deaths
Clinical observations: no signs of systemic toxicity
Dermal irritation: Signs of dermal irritation noted were very
slight erythema, haemmorrhage of dermal cappilaries, small superficail
scattered scabs, hardened light brown coloured scabs, glossy skin and
scab lifting to reveal glossy skin. There were no signs of dermal
irritation noted at the test site of one male.
Bodyweight: Animals showed expected gains in bodyweight over the
study period, except for one female which showed bodyweight loss during
the first week but expected gain in bodyweight during the second week.
Necropsy: No abnormalities were noted
Conlusion: The acute dermal median lethal dose (LD50) of the test
item in the Wistar strain rat was found to be greater than 2000mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again