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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004-2006
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with acceptable restrictions

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
2006
Reference Type:
publication
Title:
Unnamed
Year:
2007

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Test type:
acute toxic class method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
In order to substantiate this evaluation, the Tecarn-Tecnologia Ambiental Ltda accredited before the Ministry of Agriculture and is holder of bio-safety certificates.
SMS samples were collected in CST´s processing plants. The crushed stone is from Brasitalia quarry, located in the municipality of Serra, Brasilia. Crushed stone samples were collected and prepared by the company Kaerne Engenharia Ltda. In compliance with the method defined in NBR 10.007.2007.

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
In the case of products mortality was not observed with the minimum dosage DL50 will be considered as higher than 2000 mg/kg.
No. of animals per sex per dose:
3
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: highest and only concentration tested
Mortality:
none observed
Clinical signs:
none reported
Body weight:
not reported
Gross pathology:
not reported
Other findings:
none reported

Any other information on results incl. tables

SMS: LD50> 2000 mg/kg

Crushed stone: LD50> 2000 mg/kg

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
SMS: LD50 > 2000 mg/kg
Crushed stone: LD50 > 2000 mg/kg
Executive summary:

To examine the oral toxicity of slags, steelmaking (SMS), and crushed stone from a quarry in the vicinity of Serra, Brasilia, tests were performed following OECD guideline 423 in Wistar rats. Fine-ground BOS, SMS and crushed stone were dosed by gavage, in their original form, at 2 g/kg bw (body weight). After dosing, the animals were observed for a post exposure period of 14 days. The LD50 was > 2000 mg/kg bw for each test material.

Slags, steelmaking (SMS), and natural stone from a quarry in Serra, Brasilia, are not toxic via the oral route,and do not need to be classified as oral toxicants. No signal word and no hazard statement is required.