Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 292-587-7 | CAS number: 90640-66-7
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: exposure measurements
Data source
Reference
- Reference Type:
- publication
- Title:
- Exposure to low molecular polyamines during road paving
- Author:
- Levin, J.O., Andersson, K., Hallgren, C.
- Year:
- 1 994
- Bibliographic source:
- Ann occup. Hyg., Vol. 38, No 3. pp. 257 264.
Materials and methods
- Type of study / information:
- Measurement of TEPA in the air during road pavement.
- Endpoint addressed:
- other: occupational exposure
- GLP compliance:
- no
Test material
- Reference substance name:
- Amines, polyethylenepoly-, tetraethylenepentamine fraction
- EC Number:
- 292-587-7
- EC Name:
- Amines, polyethylenepoly-, tetraethylenepentamine fraction
- Cas Number:
- 90640-66-7
- Molecular formula:
- C8H23N5, C10H25N5
- IUPAC Name:
- (2-aminoethyl)[2-({2-[(2-aminoethyl)amino]ethyl}amino)ethyl]amine; bis(2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine
- Test material form:
- liquid
Constituent 1
Method
- Exposure assessment:
- measured
- Details on exposure:
- TEPA was found as aerosol
Results and discussion
- Results:
- TEPA was measured in concentrations of 0.02 to 0.05 mg/m³.
Applicant's summary and conclusion
- Executive summary:
Fatty amine wetting agents are used to increase adhesion in bitumen emulsions used in road paving, but commercial fatty amine products are contaminated with low molecular polyamines and alkanol polyamines which are released from the hot bitumen during paving. Polyamines and alkanol polyamines are known to cause eye and respiratory tract irritation and skin sensitization. The exposure of road pavers to ethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, hydroxyethylethylenediamine, hydroxyethyldiethylenetriamine, monoethanolamine and diethanolamine was studied, since most of these compounds were found in the products used. Personal and static air sampling was performed during road paving. A highly sensitive measurement technique utilizing naphthylisothiocyanate-coated sorbents and filters was used. Exposure was found to be in the range <0.02-0.5 mg/m³, as total concentration of low molecular polyamines and alkanol polyamines. Since the polyamines and alkanol polyamines in question are highly irritating they may contribute to the symptoms experienced by the road pavers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
