Registration Dossier
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EC number: 215-222-5 | CAS number: 1314-13-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Nanomaterial dustiness
Administrative data
- Endpoint:
- nanomaterial dustiness
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The method is recommended in the respective ECHA guidance and was regarded as suitable to determine the distribution of particles of respirable or inhalable size. However, only limited documentation of the data evaluation was provided in the full study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to
- Guideline:
- EN 15051 (Workplace atmospheres - Measurement of the dustiness of bulk materials - Requirements and reference test methods)
- Version / remarks:
- 2006
- Deviations:
- not specified
- GLP compliance:
- no
- Type of method:
- rotating cylinder
- Details on methods and data evaluation:
- The dustiness of the sample powder will be carried out using the rotating drum method specified in the new European standard of the dustiness of bulk samples (EN15051). This device uses two porous size-selective foam stages and a filter to provide information about the dustiness of the powders in terms of the inhalable, thoracic and respirable fractions of the dust dispersed. Three replicate tests of the powder will be carried out to obtain an estimate of the precision of the measurements. The standard also requires simple moisture content measurements to be made for each material, as dustiness has been found to be a function of moisture content. Analysis is carried out at 50+5% relative humidity. For each measurement 35 ml will be tested.
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- solid: nanoform
Results and discussion
Any other information on results incl. tables
Table1. Mean and SD of the dustiness results (in terms of the inhalable, thoracic and respirable fractions of dust dispersed) and moisture content of the PROSPEcT sample powders.
Sample Name | Supplier | Batch number | Inhalable fraction (mg kg−1) | Thoracic fraction | Respirable fraction | Moisture content (%) | ||||
Mean | SD | Mean | SD | Mean | SD | Mean | SD | |||
NM110 | BASF, | ZC250#78 | 2905 | 371 | 599 | 239 | 27 | 3 | 0.5 | 0.10 |
NM111 | BASF, | ZB250#64 | 5880 | 610 | 1340 | 241 | 138 | 105 | 0.3 | 0.00 |
NM112 | Micronisers, | ZA250#30 | 1095 | 222 | 317 | 37 | 42 | 8 | 1.2 | 0.20 |
NM113 | Sigma, | ZrA250#33 | 166 | 26 | 34 | 10 | 10 | 2 | 0.4 | 0.10 |
Table2. The calculated coefficient of variation (COV) values of the results inTable1. The coefficient of variation is the ratio of the standard deviation to the mean. It is a measure of variability in relation to the mean and is used to compare the relative dispersion in one type of data with the relative dispersion in another type of data. The data to be compared may be in the same units, in different units, with the same mean, or with different means.*
Sample Name | Inhalable fraction (mg kg−1) | Thoracic fraction | Respirable fraction | Moisture content (%) |
COV (%) | COV (%) | COV (%) | COV (%) | |
NM110 | 12.8 | 39.9 | 12.7 | 21 |
NM111 | 10.4 | 18.0 | 76.2 | 0 |
NM112 | 20.3 | 11.5 | 19.9 | 18 |
NM113 | 15.8 | 29.5 | 17.6 | 34 |
Applicant's summary and conclusion
- Executive summary:
NPL, 2010 investigated the dustiness of the nanomaterials. The dustiness of the sample powder was carried out using the rotating drum method specified in the new European standard of the dustiness of bulk samples (EN15051). Three replicate tests of the powder were carried out to obtain an estimate of the precision of the measurements. The standard also requires simple moisture content measurements to be made for each material, as dustiness has been found to be a function of moisture content. Analysis was carried out at 50 + 5 % relative humidity. For each measurement 35 mL was tested. Test results of the dustiness studies showed a significant difference in the inhalable dustiness levels. The respirable dustiness index, however, was quite comparable and possibly influenced by larger variation than the inhalable dust fraction. The inhalable dustiness index is classified to be at the high end of “low” dustiness (NM‑110) to just “moderate” (NM‑111). This compares approximately to the levels of nanoparticle powders of goethite, organoclay and talc compared to dustiness data on other test nanomaterials. For Respirable dust both samples are in the lower “moderate” dustiness range (range: 50 to 250 mg/kg).
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