Registration Dossier
Registration Dossier
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EC number: 940-510-9 | CAS number: 103043-58-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: Calculated
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Validated QSAR System-Substance is in domain of the system.
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A quantitive structure-activity relationship (QSAR) system for the estimation of the skin sensitization potency that incorporates skin metabolism and considers the potential of parent chemicals and/or their activated metabolites to react with skin proteins, was conducted. A chemically divers training set of substances was used and their skin sensitization potency assigned to one of three classes.
- GLP compliance:
- no
- Type of study:
- other: QSAR
Test material
- Reference substance name:
- Bis(2-ethylhexyl) adipate
- EC Number:
- 203-090-1
- EC Name:
- Bis(2-ethylhexyl) adipate
- Cas Number:
- 103-23-1
- IUPAC Name:
- bis(2-ethylhexyl) adipate
- Details on test material:
- Please refer to confidential details on test material
Constituent 1
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: no data
Any other information on results incl. tables
QSAR was used that predicted the test substance as not sensitizing.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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