Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
specific investigations: other studies
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication that meets acceptable scientific criteria.

Data source

Reference
Reference Type:
publication
Title:
Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans.
Author:
Reddy JK, Lalwani ND
Year:
1983
Bibliographic source:
CRC Critical Reviews in Toxicology, 12:1–58.

Materials and methods

Test material

Constituent 1
Reference substance name:
Bis(2-ethylhexyl) adipate
EC Number:
203-090-1
EC Name:
Bis(2-ethylhexyl) adipate
Cas Number:
103-23-1
IUPAC Name:
bis(2-ethylhexyl) adipate

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Route of administration:
oral: feed
Details on exposure:
0 .25, 0.5, 1, and 2% (w/w) DEHA in feed
Duration of treatment / exposure:
30 days

Results and discussion

Applicant's summary and conclusion

Executive summary:

A comparative study for peroxisome proliferators was conducted with several substances, including DEHA. Rats and mice were fed up to 2% DEHA for 30days. Peroxisome proliferating effects were detected.

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