Registration Dossier
Registration Dossier
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EC number: 940-510-9 | CAS number: 103043-58-9
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication that meets acceptable scientific criteria.
Data source
Reference
- Reference Type:
- publication
- Title:
- Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans.
- Author:
- Reddy JK, Lalwani ND
- Year:
- 1 983
- Bibliographic source:
- CRC Critical Reviews in Toxicology, 12:1–58.
Materials and methods
Test material
- Reference substance name:
- Bis(2-ethylhexyl) adipate
- EC Number:
- 203-090-1
- EC Name:
- Bis(2-ethylhexyl) adipate
- Cas Number:
- 103-23-1
- IUPAC Name:
- bis(2-ethylhexyl) adipate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: feed
- Details on exposure:
- 0 .25, 0.5, 1, and 2% (w/w) DEHA in feed
- Duration of treatment / exposure:
- 30 days
Results and discussion
Applicant's summary and conclusion
- Executive summary:
A comparative study for peroxisome proliferators was conducted with several substances, including DEHA. Rats and mice were fed up to 2% DEHA for 30days. Peroxisome proliferating effects were detected.
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