Registration Dossier
Registration Dossier
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EC number: 940-510-9 | CAS number: 103043-58-9
Endpoint summary
Administrative data
Description of key information
Additional information
DPHA is not expected to be bioaccumulative. Due to their readily biodegradable nature, extensive degradation of the substance in conventional STPs will take place and only low concentrations are expected to be released into the environment. Once present in the aquatic compartment, further biodegradation will occur and, depending on their log Pow, water solubility and adsorption potential, DPHA will be bioavailable to aquatic organisms such as fish mainly via water or on the other hand via feed and contact with suspended organic particles. After uptake by fish species, extensive and fast biotransformation of DPHA by carboxylesterases into adipic acid and via 2-propylheptanol to 2-propylheptanoic acid is expected. The alcohol is used by these organisms as their main source of energy throughout all the different life stages (early development, growth, reproduction, etc.). Adipic acid does not have the potential to accumulate in adipose tissue due to their low log Pow. The key study with the read across substance reports a BCF value of 27, which clearly indicate that rapid metabolism takes place even when log Pow values are above the trigger value of 4.5. Supporting BCF/BAF values estimated using BCFBAF v3.01 confirm the experimental result (all well below 2000).
The information above provides strong evidence supporting the statement that rapid metabolism and low bioaccumulation potential can be expected for DPHA and its metabolites.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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