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EC number: 627-034-4
CAS number: 1213789-63-9
In an OECD
TG 401 study, the test substance "Noram O" (oleylamine), an opaque,
non-homogenous liquid (purity 97.9%), was orally applied to Sprague
Dawley rats at a doses of 2000, 1000, 500 and 200 mg/kg bw. In a
pre-test (limit test) with 2000 mg/kg bw, no vehicle was used. The
substance was heated to approximately 30°C and mixed with corn oil for
the lower dose groups in the main test. Mortalities were 70, 20, 0, and
10% in the respective dose groups. Males (LD50 approximately 1200 mg/kg
bw) were more sensitive compared to females (LD50 approximately 2000
mg/kg bw); the LD50 for both sexes was established at 1689 mg/kg (probit
analysis). Clinical signs included: hypokinesia and/or sedation,
piloerection and dyspnea, abdominal swelling. Decreases in body weight
gain were noted between day 1 to 5 at 200 and 500 mg/kg bw, persisting
in one male and one female at 200 mg/kg bw; and at 1000 mg/kg and
returning to normal by day 8. Body weight gain was also decreased at
2000 mg/kg bw from day 1 to 8, returning to normal by day 15. No
abnormalities were noted at necropsy
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