Registration Dossier
Registration Dossier
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EC number: 500-047-1 | CAS number: 26316-40-5 1 - 4.8 moles ethoxylated and 1 - 8.5 moles propoxylated
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2d: Test procedure in accordance with national standard methods with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Register, 1978, 43, 37355-6
- Principles of method if other than guideline:
- Single exposure for 24 h to single dose of 5000 mg/kg undiluted. Observation period 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Details on test material:
- EDA, EO + PO
Lot TB11170-841
Based on producers products specs information from the producer (not available in the report) the test material was 70–90% PO and 10–30% EO and has a Molecular Mass of (average Mn = 280 g/mol)
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- male/female
Administration / exposure
- Vehicle:
- other: undiluted
- Doses:
- 5000 mg/kg single dose
- No. of animals per sex per dose:
- 2
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
Any other information on results incl. tables
All rabbits survived and no signs of systemic toxicity were observed following application of the test material. No redness swelling of necrosis was observed on the treatment site when the sleeves were removed. Pre treatment weight was regained 1 week post-treatment. Upon gross pathological examination, mild petechial hemorrhages were observed in the subcutaneous fat and fascia at applications sites. Underlying muscle was not involved. The skin was viable and intact. No other lesions attributable to treatment were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dermal LD50 of >5000 mg/kg: no EU classification for acute oral toxicity.
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