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Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: irrelevant test material ("fibre treated with ATO")

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970

Materials and methods

Endpoint addressed:
skin irritation / corrosion
Test guideline
Guideline:
other: No guideline specified.
Principles of method if other than guideline:
A combined test was conducted to determine the irritation and sensitisation potential of a fibre treated with a mixture of antimony oxide (Sb2O3) and a substance of which the identity was deleted from the report. The fibre contained 1% antimony oxide and were applied to the arms of ten men
and to the arms or legs of ten women and held in place with adhesive tape for six days. Two weeks after removal, new patches were applied for 48 hours. Skin under the patches was examined at two and six days and on final day at patch removal.
In a similar test fibre containing Sb2O3 was applied to the arms of 46 men and to the arms or legs of 127 women and held in place with adhesive tape for six days.
GLP compliance:
no
Remarks:
not applicable

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): fibre treated with antimony trioxide
- Physical state: solid
- no other details on test material are stated

Method

Type of population:
general
Details on study design:
1.
- tested at 10 men and 10 women
- fibre treated with a mix of antimony oxide and a substance of which the identity was deleted from the report
- fibre contained 1% antimony oxide (by weight)
- one-inch squares of the test fabric were applied to the arms of ten men and to the arms or legs of ten women
- fibre squares held in place with adhesive tape for six days
- two weeks after removal, new patches were applied for 48 hours
- skin under the patches was examined at two and six days and on final day at patch removal

2.
- fibre treated with a mix of antimony oxide and a substance of which the identity was deleted from the report
- fibre contained 1% antimony oxide (by weight)
- one-inch squares of the test material were applied to the arms of 46 men and to the arms or legs of 127 women
- fibre squares held in place with adhesive tape for six days
- two weeks after removal, new patches were applied as a challenge for the skin sensitisation and were removed after 48 hours
- skin under the patches was examined at two and six days and on final day at patch removal

Results and discussion

Results:
1.
No skin reactions were seen at any of the examinations.

2.
After six days of occluded wear one subject had paplues along the edge of patch area, however, similar paplues were also seen under the tape area. Subjects had small indented areas under patch that appeared as red spots that coincided with the crimed pattern of this fibre.

Any other information on results incl. tables

1.

The study shows that one-inch squares of a test fabric of unknown identity containing 1% antimony oxide was not irritating to the skin of 10 men and 10 women. The amount of antimony trioxide applied was not given and there is no information on how much of the antimony trioxide in the fibre that came into contact with the skin. Therefore, no conclusions on the irritation potential of antimony trioxide can be drawn from this study.

2.

No conclusions on the irritation potential of antimony trioxide can be drawn from this study.

This study shows that one-inch squares of a test fabric of unknown identity containing an unknown amount of antimony trioxide were not irritating to the skin of 46 men and 127 women. Since the amount of antimony trioxide applied was not given and there is no information on how much of the antimony trioxide in the fibre that came into contact with the skin no conclusion on the irritation potential of antimony trioxide can be drawn from this study.

Applicant's summary and conclusion