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EC number: 291-445-1 | CAS number: 90411-68-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 - 13 Jun 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions: The study is not performed under GLP conditions. No test substance monitoring is performed.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- but performed according to ISO 17025
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Test solutions are prepared in accordance with the OECD monography n°23. Aqueous daphnia test medium is saturated with the substance to be tested by dynamic contact setting with a known test substance amount. The preparation consists of 68 h of gentle agitation by magnetic stirring to obtain a vortex of about 1/3 (or less under some conditions) of the height between the top and the bottom of the flask, followed by 4 h of phase separation.The aqueous phase, containing the soluble substances is taken to perform the test. The test solution is identified to its loading rate (massic proportion of substance to be tested/ test medium mass introduced into the diphasic reactor) while operating the Water accomodated fraction (WAF). The implemented loaded ratio is : 0.10/1000. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: in-house culture (obtained by acyclic parthenogenese; minimum second generation)
- Age at study initiation: < 24 h
- Method of breeding: Daphnia are hold in dilution water according to OECD guideline 202. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 21 ± 1 °C
- pH:
- 7.8 ± 0.2 (7.7 at end of test in control and treatment)
- Dissolved oxygen:
- > 7 mg/L
- Nominal and measured concentrations:
- Nominal: 100 mg/L loading rate WAF
- Details on test conditions:
- TEST SYSTEM
- Test vessel: test tube
- Size: 100 mL; Fill volume: 100 mL
- No. of organisms per vessel: 10
- No. of vessels per concentration: 2
- No. of vessels per control: 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to OECD guideline 202
- Culture medium different from test medium: no
- Intervals of water quality measurement: not specified
OTHER TEST CONDITIONS
- Photoperiod: The test is performed in darkness.
EFFECT PARAMETERS MEASURED: Immobilisation was recorded after 24 and 48 h test duration. - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Details on results:
- No mortality was observed in the control and the treatment during the test period of 48 h. The daphnia did not show any abnormal behaviour during the test and no external apparent impact was detected.
Reference
Description of key information
No toxic effects up to the limit of water solubility (< 0.15 mg/L) for Daphnia magna (OECD 202)
Key value for chemical safety assessment
Additional information
One study investigating the short-term toxicity of Hexanoic acid, 2-ethyl-, C16-18 alkyl esters (CAS No. 90411-68-0) to aquatic invertebrates is available. The non-GLP study was conducted under static conditions according to OECD guideline 202 using Daphnia magna as test organism (Bouillon, 2012). A 100 mg/L loading rate WAF was tested in a limit test. No mortality was observed in the treatment and the control throughout the test period of 48 h. Hence, a 48 h-EL50 is determined to be > 100 mg/L based on the nominal test concentration.
A detailed reference list is provided in the technical dossier (see IUCLID, section 13) and within the CSR.
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