Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.1 mg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
1 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.01 mg/L
Assessment factor:
10 000
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
2.19 mg/L
Assessment factor:
100
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
2.69 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.269 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.603 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Where possible, PNEC calculations have been undertaken using default assessment factors in accordance with ECHA guidance on information requirements and chemical safety assessment Chapter R.10: Characterisation of dose [concentration] response for environment.PNECs were derived from the study with the most sensitive species available for each compartment/endpoint. Algae are the most sensitive species to the toxic effects of 4 -MHHPA in the aquatic compartment with an acute EC50 of 135 mg/L (based on growth rate). However, acute tests with fish and daphnids showed no toxicity at a limit concentration of 100 mg/L and LC50s were not established. As a result a value of 100 mg/L has to be regarded as the lowest value for PNEC derivation.

Conclusion on classification

Acute toxicity:

Algae are the most sensitive species to the toxic effects of 4 -MHHPA with an acute EC50 of 135 mg/L (based on growth rate). Based on the results obtained in the aquatic toxicity studies, 4 -MHHPA need not be classified regarding acute toxicity to the environment.

Although 4 -MHHPA is not regarded as being readily biodegradable, classification is not justified based on the low toxicity observed in acute studies at three trophic levels, and low potential for bioaccumulation.

Overview of Results used for Classification and Labelling:

Fish, short-term, freshwater: LC50 > 100 mg/L

Daphnia magna, short-term, freshwater: LC50 > 100 mg/L

Algae, freshwater: LC50 = 135 mg/L