Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-094-1 | CAS number: 25550-51-0
Endpoint summary
Administrative data
Description of key information
Additional information
Ready biodegradability of 4-methylhexahydrophthalic anhydride by a non-adapted activated sludge has been investigated according to OECD/EU test methods using a Manometric Respirometry Test. After 28 days the mean biodegradation was 2% and the test substance must be regarded as not readily biodegradable. A toxicity control containing both test and reference substances demonstrated that degradation of the reference substance was not inhibited by the test substance indicating that the test substance is not inhibitory to STP microorganisms.
4-methylhexahydrophthalic anhydride (4-MHHPA) hydrolyses almost instantaneously on contact with water, to give 4-methylhexahydrophthalic acid (4-MHHPAc, CAS 57567-84-7). A hydrolysis study according to OECD guideline no. 111 was carried out and the half-life (DT50) at pH 7 and 20°C was estimated to be 1.90 minutes.
The biodegradability of the acid degradation product was calculated using the software BIOWIN v4.10.The results indicate that 4-methylhexahydrophthalic acid is expected to be readily biodegradable.
Moreover, modelling of possible biodegradation pathways indicate that aerobic degradation is likely, intermediate degradation products being predicted which have been shown to be readily biodegradable.
Although QSAR estimations result in readily biodegradability environmental exposure was assessed by using the term “not biodegradable” as a worst case.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
