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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only pathological-anatomical and histopathological findings

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified
Remarks:
pre GLP
Limit test:
no

Test material

Constituent 1
Reference substance name:
(1-hydroxyethylidene)bisphosphonic acid, sodium salt
EC Number:
249-559-4
EC Name:
(1-hydroxyethylidene)bisphosphonic acid, sodium salt
Cas Number:
29329-71-3
Molecular formula:
C2H8O7P2.xNa
IUPAC Name:
(1-hydroxyethylidene)bisphosphonic acid, sodium salt

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose only
Vehicle:
other: no data
Remarks on MMAD:
MMAD / GSD: No data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
14 days (plus 14 day recovery period)
Frequency of treatment:
Daily, but period not stated.
Doses / concentrations
Dose / conc.:
0.5 mg/m³ air
Control animals:
yes
Details on study design:
Post-exposure period: 14 days

Results and discussion

Effect levels

Dose descriptor:
NOAEC
Effect level:
>= 0.5 mg/m³ air
Sex:
male/female

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

After 14 day nose exposure inhalation to 0.5 mg/m3 and after 14 day recovery period there were no detectable histological alterations in the nose, larynx and trachea.

Applicant's summary and conclusion

Conclusions:
In a subacute repeated dose toxicity study a salt of HEDP was administered to Wistar rats, nose-only, for 14 days, a NOAEC of 0.5 mg/m3 was established.
Executive summary:

In a subacute repeated dose inhalation toxicity study, a salt of HEDP (actual salt tested not clear) was administered to Wistar rats, nose-only, for 14 days (length of exposure period per day not stated) at a concentration of 0.5 mg/m3. There was also a 14 day recovery period. There were no detectable histological alterations in the nose, larynx and trachea. Therefore the NOAEL was at least 0.5 mg/m3.