Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

basic toxicokinetics
Data waiving:
other justification
Justification for data waiving:

Data source

Reference Type:
secondary source

Materials and methods

Test guideline
no guideline available
GLP compliance:
not specified

Administration / exposure

Route of administration:

Results and discussion

Applicant's summary and conclusion

Executive summary:

There are no dermal penetration/absorption studies available for Sa 190. Dermal penetration strongly depends on the molecular weight of a substance and its lipophilic properties. Typically a molecular weight above 500 prevents a substance from penetrating the skin. The lipophilic properties of a chemical are indicated by the octanol-water partition coefficient (log Kow). Substances with a molecular weight below 500 and log Kowvalues between +1.0 and +4.0 are assumed to be able to penetrate the skin. Log Kowvalues below +1.0 or above +4.0 indicate decreasing penetration ability while log Kowvalues below -1.0 or above +6.0 suggests that a substance is not likely to penetrate the skin*.

Sa 190 has a molecular weight of 423.72 and a log Pow of >5.7. According to this data it must be considered that Sa 190 might be able to penetrate the skin, though to a limited extent. There is no information available to predict the fate of Sa 190 after dermal penetration. However, taking into account its physico-chemical properties it is likely to become degraded by releasing its starting monomers.


*Basic principles according to: US-EPA “Dermal Exposure Assessment: Principles and Applications”. EPA/600/8-91-011B, January 1992