Registration Dossier

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Distribution of Label after Intragastric Adminstration of Be-labeled Carbon to Weanling and Aged Mice
Author:
LeFevre ME and Joel DC
Year:
1986
Bibliographic source:
Distribution of Label after Intragastric Adminstration of Be-labeled Carbon to Weanling and Aged Mice. Poceedings of the Society for Experimental Biology and Medicine 182, 112-119.

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Carbon black
EC Number:
215-609-9
EC Name:
Carbon black
Cas Number:
1333-86-4
Molecular formula:
C
IUPAC Name:
Carbon black
Test material form:
solid: pellets
Radiolabelling:
not specified
Remarks:
Be

Test animals

Species:
mouse

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Any other information on results incl. tables

Absorption of carbon black from gastro-intestinal tract was low in mice, with only small amount found in Peyer’s patches

Applicant's summary and conclusion

Conclusions:
Absorbtion of carbon black via oral exposure route is low
Executive summary:

Absorbtion of carbon black via oral exposure route is low