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EC number: 915-623-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Test material form:
- liquid: viscous
- Details on test material:
- - Substance type: Technical product.
- Storage condition of test material: No data.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: David Percival Ltd., Moston, Sandbach, Cheshire, UK.
- Age at study initiation: 12-16 weeks.
- Weight at study initiation: 2.21-2.93 kg.
- Housing: animals were individually housed in suspended metal cages.
- Diet: ad libitum.
- Water: ad libitum.
- Acclimation period: minimum period of five days.
ENVIRONMENTAL CONDITIONS
- Temperature: 19-22°C.
- Humidity: 60-65%.
- Air changes: approximately 15 air-changes per hour.
- Photoperiod: 12 hours dark / 12 hours light.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 ml. - Duration of treatment / exposure:
- Four hours.
- Observation period:
- 72 hours.
- Number of animals:
- Three rabbits.
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm.
- Type of wrap if used: gauze patch.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): residual test material was removed by gentle swabbing with cotton wool soaked in diethyl ether.
- Time after start of exposure: 4 hours.
SCORING SYSTEM: Approximately one hour following the removal of the patches, and 24, 48 and 72 hours, the test sites were examined for evidence of primary irritation and scored according to the Draize scale (0 = no reaction ; 4 = severe reaction)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #1, #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 0.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: Individual mean scores: #1 0.3, #2 0.7, #3 0.3.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #1, #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Very slight erythema was noted at two treated skin sites one hour after patch removal, at all treated skin sites at the 24-hour observation and at one
treated skin site at the 48-hour observation. All treated skin sites appeared normal 72 hours after treatment (see Table 1).
Any other information on results incl. tables
Table 1: Mean scores for dermal irritation
Skin reaction |
Reading (hours) |
Individual scores |
||
Female (2.93 kg) |
Male (2.65 kg) |
Male (2.21 kg) |
||
Erythema/Eschar Formation |
1 |
0 |
1 |
1 |
24 |
1 |
1 |
1 |
|
48 |
0 |
1 |
0 |
|
72 |
0 |
0 |
0 |
|
Oedema Formation |
1 |
0 |
0 |
0 |
24 |
0 |
0 |
0 |
|
48 |
0 |
0 |
0 |
|
72 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to Regulation 1272/2008/EC.
- Conclusions:
- Based on the results of a GLP-compliant guideline study, the substance is considered to be not irritating to rabbit skin.
- Executive summary:
Skin irritating/corrosive effects of 2-amylanthraquinone were studied in 3 albino rabbits. 0.5 ml of 2-amylanthraquinone was applied on the shaved skin of test animals under semi-occlusive coverage. After 72 hours of observation no signs of skin irritation or corrosion were present. The test substance is considered to be non irritating to the skin of albino rabbit under the conditions of this study.
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