Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 286-344-4 | CAS number: 85209-91-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented and reported study fully adequate for assessment. The study was conducted according to internationally accepted technical guidelines and in compliance with GLP in a recognized contract research organization.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,4,8,10-tetra(tert-butyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxide, sodium salt
- EC Number:
- 286-344-4
- EC Name:
- 2,4,8,10-tetra(tert-butyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxide, sodium salt
- Cas Number:
- 85209-91-2
- Molecular formula:
- C29H43O4P.Na
- IUPAC Name:
- sodium 5,7,13,15-tetra-tert-butyl-10-oxo-9,11-dioxa-10λ⁵-phosphatricyclo[10.4.0.0³,⁸]hexadeca-1(12),3,5,7,13,15-hexaen-10-olate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Adult albino rabbits, Hra:(NZW)SPF
- Source:Hazleton Research Products, Inc., Denver PA
- Weight at study initiation: 2032 - 2116 g
- Housing: individually in screen-bottom cages,
- husbandry and housing: addording to "Guide for the Care and Use of Laboratory Animals" (NIH Publication No. 86-23 (revised 1985)).
- Diet (e.g. ad libitum): measured, High Fiber Rabbit Chow® 5326, Purina Mills, Inc.
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
- Temperature (°C): 18.9-23.3
- Humidity (%):48 to 55
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- physiological saline
- Controls:
- no
- Amount / concentration applied:
- - Amount(s) applied (volume or weight with unit): 0,5 g test material (moistened with 0,9% saline)
VEHICLE
- Concentration (if solution): 0,9% saline - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 30 minutes = 4 hours; 24, 48, and 72 hours after patch removal
- Number of animals:
- 6 (3 male, 3 female)
- Details on study design:
- TEST SITE
- Area of exposure: 2,5 cm x 2,5 cm
- Type of wrap if used: gauze patch secured with paper tape, loosely overwrapped with Saran Wrap® and secured with Elastoplast® tape to provide a
semiocclusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): lukewarm water
- Time after start of exposure: 4 h
SCORING SYSTEM:according to the Draize technique (Draize, J.H. 1975)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- no erythema, no edema observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritant
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
