Registration Dossier
Registration Dossier
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EC number: 203-470-7 | CAS number: 107-18-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A maximisation test was conducted with Hartley strain male Guinea pigs to determine the sensitisation potential of allyl alcohol. For the first (intradermal) induction, a 1 w/v% allyl alcohol solution was used and the second (topical) induction used 2.5 w/v% allyl alcohol solution. The challenge dose (undiluted test substance) was applied 21 days after the first induction treatment, by topical
(24h occlusively patched) application to the lateral flank.
Reactions were scored 24 and 48 hours after challenge patch removal: no adverse skin reactions were seen in any test or negative control animals. The positive control (DNCB) showed positive skin reactions as expected. Based on the results of this study, allyl alcohol is not considered to be a skin sensitiser.
Migrated from Short description of key information:
One key study has been identified as having adequately assessed the contact sensitising potential of allyl alcohol.
Justification for classification or non-classification
Based on the results of the key study (Guinea pig maximisation test for skin sensitisation), allyl alcohol is not classified as a skin sensitiser under:
- Directive 67/548/EEC criteria
- Regulation 1272/2008 (EU CLP GHS) criteria
- UN GHS criteria.
No classification for sensitisation is applied to allyl alcohol in Annex VI of the CLP Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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