Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 203-470-7 | CAS number: 107-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A maximisation test was conducted with Hartley strain male Guinea pigs to determine the sensitisation potential of allyl alcohol. For the first (intradermal) induction, a 1 w/v% allyl alcohol solution was used and the second (topical) induction used 2.5 w/v% allyl alcohol solution. The challenge dose (undiluted test substance) was applied 21 days after the first induction treatment, by topical
(24h occlusively patched) application to the lateral flank.
Reactions were scored 24 and 48 hours after challenge patch removal: no adverse skin reactions were seen in any test or negative control animals. The positive control (DNCB) showed positive skin reactions as expected. Based on the results of this study, allyl alcohol is not considered to be a skin sensitiser.
Migrated from Short description of key information:
One key study has been identified as having adequately assessed the contact sensitising potential of allyl alcohol.
Justification for classification or non-classification
Based on the results of the key study (Guinea pig maximisation test for skin sensitisation), allyl alcohol is not classified as a skin sensitiser under:
- Directive 67/548/EEC criteria
- Regulation 1272/2008 (EU CLP GHS) criteria
- UN GHS criteria.
No classification for sensitisation is applied to allyl alcohol in Annex VI of the CLP Regulation.
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