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EC number: 203-470-7 | CAS number: 107-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed publication. The method used is similar to OECD 402, but predates GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicity of allyl alcohol.
- Author:
- Dunlap, M.K., Kodama, J.K., Wellington, J.S., Anderson, H.H., Hine, C.H.
- Year:
- 1 958
- Bibliographic source:
- AMA Archives of Industrial Health. 18:303-311
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Only three rabbits per group used, observation period not less than 10 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Allyl alcohol
- EC Number:
- 203-470-7
- EC Name:
- Allyl alcohol
- Cas Number:
- 107-18-6
- Molecular formula:
- C3H6O
- IUPAC Name:
- prop-2-en-1-ol
- Details on test material:
- Allyl alcohol was 98.5% pure and was provided by the Shell Chemical Company. (Impurities are diallyl ether and water).
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1.3 - 3.9 kg
- Housing: Housed individually in cages
- Diet (e.g. ad libitum): standard pellets ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- coverage: 3x3 cm
- Type of wrap if used: Rubber dam sealed with rubber cement and subsequently wrapped with toweling and adhesive tape to prevent slipping of the seal.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.025 - 0.20 g/kg
- Constant volume or concentration used: yes - Duration of exposure:
- No details
- Doses:
- 0.025 to 0.20 g/kg of allyl alcohol. (no further details).
- No. of animals per sex per dose:
- Four groups of three rabbits used.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology, gross pathology
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 89 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 40 - 250
- Mortality:
- No further details
- Clinical signs:
- other: The main clinical sign was described as apathy, along with flushing of the skin. Attitude of bellicosity. Ataxia, convulsions and diarrhoea preceded death in moribund animals.
- Gross pathology:
- Oedema and congestion of the lungs, visceral congestion (presence of mucous in the intestinal tract), discoloured liver (some necrosis), swollen kidneys.
- Other findings:
- Histopathological findings: lung congestion, liver damage (congestion and necrosis of the periportal sinusoids, central pallor and necrosis), heme casts and cloudy swelling in the kidney. Rabbits that survived the observation period showed similar lesions to those that died, but less frequently.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In this study the dermal LD50 of allyl alcohol to rabbits is 89 mg/kg.
- Executive summary:
In an acute dermal toxicity study, 4 groups of 3 male albino rabbits were dermally exposed to allyl alcohol to a 3x3cm area at doses of 0.025 to 0.20 g/kg bw. Animals then were observed for at least 10 days.
Dermal LD50Males = 89 mg/kg bw (95% C.L. 40 - 250 mg/kg)
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