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Toxicity to microorganisms

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Description of key information

Three studies have been identified to assess the toxicity of allyl alcohol to microorganisms.     

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
100 mg/L

Additional information

The results of the studies used to assess the toxicity of allyl alcohol to microorganisms indicate that allyl alcohol is of low toxicity with the exception of a paper by Tomlinson et al which indicates that allyl alcohol inhibits the rate of nitrification in nitrifying bacteria. Low toxicity to microorganisms was observed in a study conducted with Tetrahymena pyriformis (IC50 ca. 4806 mg/l) and there was no evidence of toxicity to microbial inoculum at a concentration of 100 mg/l allyl alcohol in an OECD ready biodegradation test performed under GLP. Tomlinson paper cites an EC75 19.5 mg/l for allyl alcohol, however, review of the paper indicates that there could have been potential inconsistences with different batches of activated sludge used during the study and the absence of rate curves plotting inhibition of nitrification versus time for allyl alcohol make it difficult to ascertain if variance in the response of the activated sludge to the test substance affected the results obtained.

As it was not possible to ascertain the reliability of the Tomlinson paper and there are two studies available indicating that allyl alcohol is of low toxicity to microorganisms, the absence of toxicity to microorganisms (no inhibition of microbial inoculum in the OECD 301C biodegradation test) at 100 mg/l was selected as the most suitable value to derive STP PNEC.