Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Publication not peer reviewed

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1954

Materials and methods

Principles of method if other than guideline:
Described in the document
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl chloroacetate
EC Number:
203-294-0
EC Name:
Ethyl chloroacetate
Cas Number:
105-39-5
Molecular formula:
C4H7ClO2
IUPAC Name:
ethyl 2-chloroacetate

Test animals

Species:
mouse
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Doses:
2 mg/10 Gm
No. of animals per sex per dose:
10 animals per dose (10 in the experimental group and 10 in the control group)
Control animals:
yes

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
250 mg/kg bw
Mortality:
Mortality of animals treated: 8/10
Mortality of control animals: 0/10

Any other information on results incl. tables

The LD50 of EMCA in mouse (subcutaneous administration) was 250 mg/kg bw.

Applicant's summary and conclusion

Conclusions:
The LD50 of EMCA in mouse (subcutaneous administration) was 250 mg/kg bw.
Executive summary:

The LD50 of EMCA in mouse (subcutaneous administration) was 250 mg/kg bw.