Registration Dossier

Diss Factsheets

Administrative data

First-aid measures

Eye contact:
In case of contact with eyes, rinse immediately with plenty of water for 15 minutes and seek medical attention.

Skin contact:
After contact with skin, wash immediately with plenty of water. Immediately remove contaminated clothing and shoes. Wash contaminated clothing before reuse. Seek medical attention if symptoms appear.

If ingested, seek medical attention immediately and show the label.

Move to fresh air immediately. If experiencing difficulty breathing, seek medical attention.

Fire-fighting measures

Suitable extinguishing media:
Use any extinguishing media which is suitable for the surrounding fire.

Extinguishing media which must not be used for safety reasons:

Special protective equipment for firefighters:
Wear a self-contained breathing apparatus and full protective gear.

Combustion products or resulting gases:
Nitrogen oxides (NOx), Carbon monoxide, Carbon dioxide (CO2).

Accidental release measures

Personal precautions:
Wear appropriate eye, skin, respiratory protection, disposable dust impervious suit and shoe covers. Avoid dust formation.

Environmental precautions:
Do not allow material to contaminate ground water system. Prevent product from entering drains.

Methods for cleaning up:
Evacuate area. Next, use disposable towels moistened with an appropriate cleaning agent (i.e. solvent, detergent and water, etc.) to complete cleaning process. A designated HEPAvacuum can be used as an alternative cleaning method for large spills of powder. All waste must be placed in a sealable, properly labeled waste disposal bag. Over bag into a sealable, properly labeled waste disposal bag. Material must be disposed of as hazardous drug waste.

Handling and storage

Technical measures/precautions:
Handle and store per labeled instructions. Use only in an area that has proper containment or provided with appropriate exhaust ventilation.

Safe handling advise:
Wear safety glasses with side-shields and nitrile gloves when handling powders or chemically resistant gloves when handling solutions (be sure to wear appropriate chemically resistant gloves depending on the type of solvents used). Clean work surfaces at the end of each day. Do not breath fumes/dust.

Technical measures/storage conditions:
Store and transport in sealed bags contained within rigid drums or appropriate closed containers in a manner that minimizes teh potential for spillage or container damage. Store at room temperature.

Incompatible products:
No special restrictions on storage with other products.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:
Not regulated.
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Inland waterway transport (UN RTDG/ADN(R))

UN number:
Not regulated.
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Marine transport (UN RTDG/IMDG)

UN number:
Not regulated.
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Air transport (UN RTDG/ICAO/IATA)

UN number:
Not regulated.
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Exposure controls / personal protection

Engineering controls:
Ensure adequate ventilation. Use vented enclosures or fume hoods when weighing, or transferring small quantities (<500 mg) of powders. For large scale activities (greater than 500 mg), use glove boxes or contained processes supplemented with local exhaust at contaminant release points.

Respiratory protection:
When handling small quantities (between 200 mg and 500 mg) use a particular respirator (HEPA/N100 or in EU:ABEK-P3). When handling large quantities or performing higher exposure risk activities, use powered air-purifying respirators equipped with HEPA filters or air-supplied hood, helmet or hardcap. Supplied air respirators with HEPA filters may be required in the absence of effective local exhaust ventilation for control or airborne dusts.

Hand protection:
Double gloving is recommended for high exposure risk activities. Wear nitrile gloves when handling as a solid or liquid formulation. When handling solutions, wear chemical-resistant gloves appropriate for the solvent(s) making up the solution.

Eye protection:
Wear eye and face protection. Safety glasses with side-shields recommended. Goggles recommended if potential exists for direct exposure to dust or splashes.

Skin and body protection:
Disposable dust impervious protective suit and shoe covers are recommended for larger scale and high exposure risk activities. Tape gloves and boots to dust impervious suit for added protection.

Stability and reactivity

Chemical stability: stable under recommended storage conditions.
Materials to avoid: oxidising agents.
Conditions to avoid: Unknown on product.
Hazardous polymerisation: hazardous polymerisation does not occur.

Disposal considerations

Waste from residues/unused products:
In accordance with local and national regulations. Should not be released into the environment.

Contaminated packaging:
Empty packing materials should be handled according to local current procedures or according to local by-laws or national laws.