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EC number: 931-250-7
CAS number: -
In animal assays for
skin sensitisation such as the Magnusson-Kligman GPMT and the Buehler
assay, kerosines did not elicit a positive response.
In the key dermal
sensitisation study, kerosine in mineral oil was tested on male young
adult Pig/Hartley guinea pigs using a modified Buehler technique. During
the challenge phase, a second exposure of a 1:4 dilution of kerosine to
induced test animals did not yield higher response grades, severity, or
incidence than those associated with the naive challenge control group
exposed to kerosine alone. During the challenge phase, exposure of 0.2%
DNCB to induction positive control animals elicited significantly higher
response grades, severity indices, and incidence over the naive DNCB
challenge control group. The vehicle irritation control group was free
of dermal irritation during the challenge phase. Therefore, under the
conditions of this study, kerosine is not considered a delayed contact
sensitiser and DNCB induced an appropriate positive response.
In supporting studies,
kerosines were not found to be dermal sensitisers to the skin of guinea
some of the studies, due
to inherent irritative properties of the material, additional negative
controls (challenge controls) were added at the challenge phase of the
study. The irritation scores of the test material were compared to the
challenge controls and only scores in excess of these controls were
considered positive sensitisation responses.
on test data, there was no evidence of skin sensitisation; therefore,
kerosine is not classified for skin sensitisation according to EU
(EC No. 1272/2008)
Migrated from Short description of key information:
In animal assays (similar to OECD 406) for skin sensitisation, kerosines and jet fuels did not elicit a positive response .
Justification for selection of skin sensitisation endpoint:
One of 12 studies with kerosines showing similar results
are not considered skin sensitisers based on the information presented
above. Therefore, kerosines do not meet the criteria for classification
as a dermal sensitiser under EU CLP Regulation (EC No. 1272/2008).
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