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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: This study is classified as reliable without restrictions because it was carried out in a method equivalent/similar to OECD TG 402.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
64742-81-0
IUPAC Name:
64742-81-0
Constituent 2
Reference substance name:
straight run kerosine
IUPAC Name:
straight run kerosine
Test material form:
other: low viscosity liquid hydrocarbon
Details on test material:
Straight run kerosine (F-131)

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Doses:
2000 mg/kg
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw

Any other information on results incl. tables

There were no mortalities and all animals gained weight during the study.
Dermal irritation occurred at the site of application of test substance in every animal.
On the day of treatment loose stool was observed in all animals but not thereafter.
No gross abnormalities were observed at necropsy.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal LD50 for straight run kerosine is > 2000 mg/kg in male and female rabbits, based on lack of systemic toxicity at 2000 mg/kg.
Executive summary:

In an acute dermal toxicity study, groups of young adult New Zealand white rabbits (5/sex) were dermally exposed to straight-run kerosine for 24 hours to 10% of the total body surface area, at a limit dose of 2000 mg/kg bw. Animals were then observed for 14 days.

 

There was no mortality of the test animals. There was no effect of treatment on body weight. Signs of dermal irritation were present throughout the study, and erythema and dry skin were noted as abnormalities for eight animals during necropsy. Abnormal stools were noted on the first day of observation. No treatment-related systemic abnormalities were exhibited during the observation period. The dermal LD50 was determined to be > 2000 mg/kg in males and females.

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