Registration Dossier
Registration Dossier
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EC number: 208-060-1 | CAS number: 506-93-4
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3
- Endpoint:
- bioaccumulation in sediment species, other
- Remarks:
- Calculation
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Bioconcentration factor BCF of Guanidine was calculated using BCFBAF v3.01 EPI Suite 4.0
- GLP compliance:
- no
- Type:
- BCF
- Value:
- 3.162 other: L/kg wet-wt
- Remarks on result:
- other: regression-based method
- Type:
- BCF
- Value:
- 0.893 dimensionless
- Calculation basis:
- other: estimated log Kow used: -1.63
- Remarks on result:
- other: Arnot-Gobas method
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The calculation yielded a BCF = 0.8935 according to the Arnot-Gobas method and based on the estimated log Kow = -1.63 and BCF = 3.162 L/kg wet-wt according to the regression-based method. The result indicates a low potential for bioaccumulation.
- Executive summary:
The bioconcentration factor BCF of Guanidine was calculated using EpiWeb4.0, BCFBAFv3.01. The calculation yielded a BCF=3.162 L/kg wet-wt (regression-based) respective BCF=0.8935 (dimensionless) (Arnot-Gobas mehtod with logKow=-1.63).
The result indicates a low potential for bioaccumulation.
Due to mission information about the applicability of the calculation model with respect to the substance under investigetion, the reslut and the conclusion thereof should be treated with care.
Referenceopen allclose all
Description of key information
A low potential for bioaccumulation is expected.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.2 L/kg ww
Additional information
According to the measured log Kow < -1.7 a low potential for bioaccumulation is expected.
The calculation yielded a BCF = 0.8935 according to the Arnot-Gobas method and based on the estimated log Kow = -1.63 and
BCF = 3.162 L/kg wet-wt according to the regression-based method. The result indicates a low potential for bioaccumulation.
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