Registration Dossier
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EC number: 809-930-9 | CAS number: 1330-78-5
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- October 10 to November 13, 2014.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed in accordance with OECD & ASTM test guidelines in compliance with GLP.
- Justification for type of information:
- This study is read across to Phenol, isopropylated, phosphate (3:1); CAS No 68937-41-7; EC No 273-066-3.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 218 (Sediment-Water Chironomid Toxicity Test Using Spiked Sediment)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM Standard E 1706-05: Standard Test Method for Measuring the Toxicity of Sediment-Associated Contaminants with Freshwater Invertebrates.
- Deviations:
- no
- Key result
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 87 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- emergence rate
- Remarks on result:
- other: 95% confidence interval of 73.6 to 102 mg/kg.
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 37 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- development rate
- Key result
- Duration:
- 28 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 37 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- development rate
Reference
Description of key information
Sediment Toxicity
Key value for chemical safety assessment
- EC50 or LC50 for freshwater sediment:
- 87 mg/kg sediment dw
- EC10, LC10 or NOEC for freshwater sediment:
- 37 mg/kg sediment dw
Additional information
This study is read across to Phenol, isopropylated, phosphate (3:1); CAS No 68937-41-7; EC No 273-066-3.
Midges (Chironomus riparius) were exposed for 28 days to five mean measured concentrations of sediment-incorporated Reofos 35 ranging from 37 to 688 mg/kg. There were treatment-related effects observed on emergence in the 79, 187, 366 and 688 mg/kg treatment groups and development at all tested concentrations. Based on the mean measured concentrations in sediment, the 28-day EC50 value for emergence was 87 mg/kg, with a 95% confidence interval of 73.6 to 102 mg/kg. The slope of the concentration-response curve was 2.336. Based on the effects observed on development rate, the LOEC for the study was 37 mg/kg and the NOEC was <37 mg/kg.
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