Registration Dossier
Registration Dossier
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EC number: 809-930-9 | CAS number: 1330-78-5
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A weight of evidence approach is discussed.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.01 mg/L
Additional information
Long-term toxicity of tris(methylphenyl)phosphate was assessed in an early-life stage toxicity test with Jordanella floridae. The experimental procedure was based on the dutch national standard method NEN 6504: Acute toxicity test with Poecilia reticulata. The early-life stages of fish are exposed for 28 days to 5 concentrations of the test substance dissolved in water, first under static conditions, and after hatching under semi-static conditions. The test begun by placing fertilised eggs in the test chambers and is continued at least until all the fish are free-feeding. Lethal effects and quantitative growth (weight and length) as sub-lethal effects are assessed and compared with control values to determine the no observed effect concentration (NOLC/NOEC). Stability of test substance was monitored during the experiment. All results refer to measured concentration. Embryonic development took place for 5 to 6 days and within one day all fish hatched. It was shown that hatched fish are more sensitive than embryos (eggs). For the endpoint egg development, a NOEC of 1.0 mg/l was obtained. Observation on mortality and sub-lethal effects results in a NOLC and NOEC of 0.01 mg/l. As analytical monitoring was carried out, the results relate to measured concentrations. This toxicity study is classified as acceptable and satisfies generally accepted scientific standards for the early-life stage toxicity test.
3 additional studies are also included. Although limited data is reported within these, the results are considered to support a weight of evidence approach, as these are comparable to other values for long term toxicity to fish in other studies, including those on analogues.
A NOEC for long term fish toxicity is assigned as 0.01 mg/l
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