Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via inhalation route
Dose descriptor:
NOAEC
813 mg/m³
Additional information

The OECD 422 study is the only study available for the reproductive toxicity endpoint.


Short description of key information:
3-Chloropropyltrimethoxysilane was tested in an inhalation OECD 422 study (Marburger, A., 2005), whole-body in rats, up to and including the highest concentration of 100 ppm. In this study there were no signs of adverse effects on reproduction. Therefore based on these results the NOAEC was established to be at least 100 ppm (813 mg/m3).

Effects on developmental toxicity

Description of key information
3-chloropropyltrimethoxysilane was tested in an inhalation OECD 422 study (Marburger, A., 2005), whole-body in rats, up to and including the highest concentration of 100 ppm. In this study there were no signs of adverse effects on development. Therefore based on these results the NOAEC was established to be at least 100 ppm (813 mg/m3).
Effect on developmental toxicity: via inhalation route
Dose descriptor:
NOAEC
813 mg/m³
Additional information
The OECD 422 study is the only study available for the developmental toxicity endpoint.

Justification for classification or non-classification

There are no data to suggest that 3 -chloropropyltrimethoxysilane should be classified for reproductive or developmental toxicity.