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Key value for chemical safety assessment

Additional information

Information is available from reliable studies for all the required in vitro endpoints. Where there was more than one result for an endpoint the most reliable study available was chosen as key study. Where there was more than one reliable study, the most recent study was selected. The results of all the in vitro studies were in agreement. The in vivo study did not confirm the effects shown in vitro.


Short description of key information:
in vitro
Gene mutation (Bacterial reverse mutation assay / Ames test): positve with and without activation in strains TA-100 and TA-1535, and in strain TA-98 without activation
Mutagenicity in mammalian cells: positive with metabolic activation L5178Y mouse lymphoma cells (similar to OECD TG 476)
in vivo
Micronucleus assay in mouse (ip administration): Negative (similar to OECD TG 474)

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The available information for 3 -chloropropyltrimethoxysilane indicates that when tested in vitro, 3 -chloropropyltrimethoxysilane (CAS number 2530 -87 -2) induces mutations in bacterial and mammalian cells. The genetic toxicty in vitro is not confirmed in an in vivo study, so it is concluded that 3-chloropropyltrimethoxysilane is not genotoxic.