Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The key sensitisation study was selected as the only available study for this endpoint. The study was conducted in accordance with an appropriate test guideline and in compliance with GLP, and gave a clear negative result.

Migrated from Short description of key information:
In a study conducted in accordance with OECD 406 (Buehler method), and in compliance with GLP, 3-chloropropyltrimethoxysilane was not sensitising (Degussa, 1993). Induction and challenge were performed using undiluted test substance. There was no indication of irritation during induction or challenge, and no positive sensitisation responses in any test animals. There were no other substance-related effects or body weight effects in either the test or control animals.

Respiratory sensitisation

Endpoint conclusion
Additional information:

No data are available regarding respiratory sensitisation.

Justification for classification or non-classification

Based on the available in vivo skin sensitisation study, 3 -chloropropyltrimethoxysilane does not require classification for sensitisation according to the criteria set out in EU Directive 67/548/EEC or Regulation 1272/2008.