Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report Date:
1993

Materials and methods

Principles of method if other than guideline:
other: micronucleus test
GLP compliance:
yes
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Purity not stated.

Test animals

Species:
mouse
Strain:
Swiss Webster
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Doses:
0 (corn oil), 500, 1000 or 1625 mg/kg
Details on study design:
Chloropropyltrimethoxysilane (CAS No. 2530-87-2) was given to both male and female Swiss-Webster mice as a single dose by intraperitoneal injection.Exposure time = 30, 48 and 72 hours

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: micronucleus test
Effect level:
2 031 mg/kg bw
Clinical signs:
There were no signs of toxicity in male or female mice in the 500 mg/kg  group, except that 1 female exhibited ataxia during the first 
hour  post-treatment.  All of the males and females in the 1000 mg/kg group  exhibited ataxia and 2 of the males also had tremors 
during the first  hour after treatment.  In males and females treated at 1625 mg/kg CPTMO,  ataxia, tremors, and prostration were 
observed during the first hour after treatment.  Other clinical signs in the high dose females included  myoclonic jerks and vocalization.  
There were no significant clinical  observations in male or female mice from the afternoon of Day 1 through  the end of the study.

Any other information on results incl. tables

Based upon mortality data obtained in a range-finding study, 

the acute intraperitoneal LD50 for the combined sexes was calculated 

to be 2031 mg/kg chloropropyltrimethoxysilane (95% confidence 

interval, 1672 to 2456 mg/kg).

Applicant's summary and conclusion