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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1990
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study did not meet current guideline requirements because it was lacking in important criteria of today's standards and methods.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report Date:
1990

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
other: in house protocol, substantially saturated vapor
GLP compliance:
not specified
Test type:
other: Substantially saturated vapour (static)
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
other:
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
A substantially saturated vapor atmosphere was generated statically by placing a sample of A-1430 into an exposure chamber and allowing the atmosphere to equilibrate overnight (ca. 18 hr).  Animals were then placed in the chamber, maintained at an air temperature of 26 °C. 
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
Vapour was produced by enclosing ca. 100g of the test material in a sealed 100 to 151 animal chamber (under static conditions).
No. of animals per sex per dose:
5/sex/dose
Control animals:
not specified
Details on study design:
To determine the potential for adverse effects by acute exposure to vapor generated at ambient temperature from A-1430, 5 male and 5 female rats were exposed for 6 hours to a substantially saturated vapor atmosphere from the material.  The atmosphere was generated statically by placing a sample of A-1430 into an exposure chamber and allowing the atmosphere to equilibrate overnight (ca. 18 hr).  Animals were then placed in the chamber, maintained at an air temperature of 26°C.  Animals were observed for signs of toxic and/or pharmacologic effects during exposure and over a 14-day postexposure period.  Survivors were sacrificed at the end of the observation period for necropsy examination.
Statistics:
Not applicable.

Results and discussion

Mortality:
No animals died during exposure or in the postexposure observation period. 
Clinical signs:
Hyperactivity was seen during exposure and disappeared the day following exposure.
Body weight:
Animals gained weight over the two-week observation period.
Gross pathology:
Necropsy revealed no gross pathological features.

Any other information on results incl. tables

Hyperactivity at 30 minutes; animals periodically rubbed head, eyes and nose during exposure. Recovery at 1 day. No gross lesions.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The findings of a 6-hr exposure to substantially saturated vapour of 3-chloropropyltrimethoxysilane indicate a low potential for toxicity by acute inhalation exposure.