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Partition coefficient

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partition coefficient
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because the substance decomposes

Description of key information

log Kow [(3-chloropropyl)trimethoxysilane]: Not relevant due to rapid hydrolysis in contact with water but predicted to be 2.0 (QSAR)

log Kow [(3-chloropropyl)silanetriol]: -1.1 at pH 7 (QSAR)

log Kow [methanol]: 0.82 to -0.64

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
20 °C

Additional information

The requirement to conduct an n-octanol/water partition coefficient for the substance is waived because in contact with water, the substance hydrolyses rapidly to form (3-chloropropyl)silanetriol and methanol.

However, the log Kow of the parent substance has been predicted to be 2.0 at 20°C using a validated QSAR estimation method.

The silanol hydrolysis product; (3-chloropropyl)silanetriol has a predicted log Kow value of -1.1 using a validated QSAR estimation method.

Methanol has a reported log Kow value of -0.82 to -0.64 (OECD 2004).


OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004, Methanol, CAS 67-56-1.