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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian germ cell study: gene mutation
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Environmental and human safety of major surfactants. Volume 1. Anionic surfactants. Part 4. Alpha olefin sulfonates
Author:
Little, A.D.
Year:
1993
Bibliographic source:
National Technical Service (NTIS) report No. PB94-102423

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Host mediated assay with mice
GLP compliance:
not specified
Type of assay:
other: host-mediated assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): AOS
- Analytical purity: four products, 21-38% active

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intramuscular
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Post exposure period:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
5000mg/kg bw
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Examinations

Tissues and cell types examined:
Injected bacteria or yeast cells were recovered and investigated.

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
negative
Toxicity:
not specified
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Any other information on results incl. tables

The test substance was not mutagenic in bacteria and yeast when metabolized by mice.

However, propane sultone at 460 mg/kg, which was tested in parallel, was mutagenic in both systems, while 1,4-butane sultone was found to be mutagenic for S. typhimurium but not mutagenic for S. cerevisiae. Both sultones were reported to be mutagenic in bacteria in vitro (Ames assay), as well.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative