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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from Handbook or data collection. Sufficient for assessment.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1983

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
review article without detailed experimental data, occlusive application for 24 hours, only 2 non-abraded animals per dose
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
other: aqueous formulation
Details on test material:
- Name of test material (as cited in study report): C14-16 Alpha olefin sulfonate
- Physical state: liquid
- Analytical purity: not reported
- Composition of test material, percentage of components: 36.9 % C14-16 AOS
- Other: pH 7-8; Source: Ethyl Corp.

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: clipped trunk, not further specified
- Type of wrap if used: plastic sleeves


REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data, but substance was removed after 24 hours


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): not reported
- Concentration (if solution): 36.9 %
- Constant volume or concentration used: yes, constant concentration
Duration of exposure:
24 hours
Doses:
6 samples with unknown concentrations
No. of animals per sex per dose:
4 rabbits (2 abraded, 2 non-abraded, sex not specified)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: no data

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
6 300 mg/kg bw
Based on:
act. ingr.
Remarks on result:
other: ±1340, Sample 1
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 16 000
Based on:
act. ingr.
Remarks on result:
other: Sample 2
Sex:
not specified
Dose descriptor:
LD50
Effect level:
10 000 mg/kg bw
Based on:
act. ingr.
Remarks on result:
other: ±1780, Sample 3
Sex:
not specified
Dose descriptor:
LD50
Effect level:
8 000 mg/kg bw
Based on:
act. ingr.
Remarks on result:
other: ±2900, Sample 4
Sex:
not specified
Dose descriptor:
LD50
Effect level:
13 500 mg/kg bw
Based on:
act. ingr.
Remarks on result:
other: ±1420, Sample 5
Sex:
not specified
Dose descriptor:
LD50
Effect level:
9 500 mg/kg bw
Based on:
act. ingr.
Remarks on result:
other: ±1600, Sample 6
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data

Any other information on results incl. tables

Average LD50 for the test item at 36.9% was > 6000 mg/kg bw active ingredient for dermal exposure of rabbits.

According to the criteria of the DSD and the CLP regulation the test substance does not have to be classified for acute dermal toxicity.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
EU Directive 67/548/EEC: not classified
Regulation (EC) No 1272/2008: not classified