Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 931-534-0 | CAS number: 68439-57-6
Endpoint summary
Administrative data
Description of key information
Primary irritation patch test: irritating
Repeat insult human patch test: not sensitising
Additional information
Data on skin irritation in humans is available from a primary irritation patch test performed with 0.3, 1.0 and 3.0% of the test substance in water with 20 volunteers of the general population (Carabello, 1980). The results demonstrate significant skin irritation at all doses especially 24 hours after application in most of the individuals. The skin reactions observed did not fully resolve in all subjects until the last reading point 48 h after application.
Information on skin sensitisation is available from 2 repeat insult human patch tests, both sponsored by industry. In the newer one 52 individuals of the general population were exposed to a test substance concentration of 1% (Stephens, 2008). Only local irritation reactions were observed 48 and 96 hours after challenge in 24/52 and 21/52 individuals, respectively. No evidence for sensitisation was found. This result is supported by the second study (Ter Haar, 1983b) in which 88 individuals of the general population were repeatedly exposed to 8% test substance for induction and once to 4% for challenge. No evidence for contact sensitisation was found in this study, either.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
